Irwin (Ernie) Allen Rose (1926-2015)
نویسندگان
چکیده
In 1953, while still at Tufts CollegeMedical School, Mel Simpson published a landmark paper demonstrating the ATP dependence of intracellular protein degradation. A year later, after moving to the Department of Biochemistry at Yale University Medical School, Simpson described his enigmatic results in a latenight discussion with a newly minted Instructor recently arrived from postdoctoral training. Fifty years later, that young faculty member, Ernie Rose, would share the 2004 Nobel Prize in Chemistry with Avram Hershko and Aaron Ciechanover for explaining Simpson’s mystery. Their seminal discovery of ubiquitindependent protein degradation has proved as significant in our understanding of cellular regulation as the earlier discovery of protein phosphorylation. Sadly, Ernie Rose quietly passed away in his sleep on June 2, 2015 at the age of 88. Irwin (Ernie) Allen Rose was born July 16, 1926 in Brooklyn, New York to firstgeneration immigrant parents from Eastern Europe. In his early years, he enjoyed a closely knit extended family and an ethnically rich neighborhood typical of the borough. When he was 13, the family doctor advised that they move to a drier climate to counter complications from his
منابع مشابه
Irwin Rose (1926-2015).
On June 2, 2015, Irwin (Ernie) Rose died quietly in his sleep at age 88, after a long and fruitful lifetime of sleuthing for the secrets of life at the molecular level. Truly great scientists are much more than the sum of their publications and awards. This is especially true for Ernie who, when informed that he had been awarded the 2004 Nobel Prize in Chemistry, wondered aloud whether he reall...
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عنوان ژورنال:
- Cell
دوره 162 شماره
صفحات -
تاریخ انتشار 2015